Selectomics to monitor and predict the emergence of resistance to antibiotics

Selectomics to monitor and predict the emergence of resistance to antibiotics


Multiple antibiotic resistance has increased over the past decades, challenging our ability to treat bacterial infections and thwarting our ability to develop new antimicrobial agents. Many resistance genes have not evolved within the pathogenic isolates but were acquired by lateral transfer. We recently showed that genes conferring glycopeptide resistance are highly prevalent in the human flora.

Some of these genes are present in novel commensal anaerobic species of the gut suggesting that these bacteria may serve as a reservoir for resistance genes. We will use the human gut microbiome to monitor the emergence of resistance genes that could have the potential to be transferred to pathogens and address the question of how these reservoirs of resistance determinants respond to antibiotic pressure. The selectomics strategy generated by this project will constitute useful tools to assess the potency of novel chemical compounds to select for resistance.

Investigators


Michel Bergeron

CHUdeQc/Université Laval 

Co-Investigators


Jacques Corbeil 
CHUdeQc/Université Laval

Marc Ouellet
CHUdeQc/Université Laval

Paul H. Roy 
CRCHU de Québec

Sylvie Trottier 
CRCHU de Québec


Funding


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